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Ammonia concentrations in the TME are elevated compared to normal tissues, with distinct regional distribution patterns ( Both tumor and immune cells exhibit increased amino acid demands to sustain their proliferation and survival (92, 93)

While this approach may create complications in terms of attributing any demonstrated cognitive effects, assessment of the nutritional status at baseline and after supplementation will presumably help inform mechanistic questions

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Glutamate dehydrogenases in fungi: From biology to biotechnology