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NNMT inhibition as a therapeutic strategy has been explored in industry pharmaceutical pipelines (including a Pfizer program for non-alcoholic fatty liver disease that was reportedly discontinued in early clinical development), but no NNMT inhibitor has reached regulatory approval to date

Studies have shown that oral supplements of B12 and injections both offer effective treatment of deficiencies

While this hasn't been clinically validated for injectable use, the biochemistry supports it

It serves critical roles in cellular redox reactions for energy metabolism and acts as an essential substrate for key signaling enzymes regulating DNA repair, gene expression, and cell signaling