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Most notable are scenarios in which ACOs have a tight distribution of performance rates on a measure

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Available human studies are characterized by relatively small sample sizes, heterogeneity in dosing regimens, and short intervention durations, which restrict the ability to draw firm conclusions regarding efficacy and optimal therapeutic windows

Mol Neurobiol 51:209219 Sirwi A, El-Sayed NS, Albadawi DA, Koshak AE, Ibrahim SR, Mohamed GA, Abdallah HM, Rabie MA (2024) Costunolide ameliorates rotenone-induced Parkinsons disease in rat model via activation of SIRT-1/p-AMPK cascade and suppression of IL-6/STAT3 axis