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First, the high water content of hydrogels gives these materials the flexibility to mimic natural organization

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Concato et al., Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs, New England Journal of Medicine, doi:10.1056/NEJM200006223422507

If very large volumes were mistakenly injected, theoretical effects could include CNS depression, low blood pressure or breathing changes, but such overdoses are not reported at normal doses