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10.1111/j.1471-4159.2004.02716.x J Neurochem

doi: 10.1016/j.cell.2018.10.001 11 CruzatVMacedo RogeroMNoel KeaneKCuriRNewsholmeP

Severe deficiency : Weekly or biweekly injections may initially be required to correct anemia and neurological symptoms

Keap1 acts as a sensor for redox reactions, and when oxidative stress occurs, modifications to specific cysteine residues on Keap1 lead to a conformational change [18, 94]