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Although comprehensive safety data were not provided, a retrospective clinical study of 12 patients with chronic knee pain showed that 7 of those patients reported relief for more than six months following an injection of BPC-157 directly into the knee joint

Another study introduced an MMP-clearable sequence at both ends of a bioactive peptide while additionally incorporating thiol-functionalized crosslinkers at each end, thus developing C-IPESLRAG-bioactive peptide-IPESLRAG-C-G to enable conjugation with norbornene-functionalized PEG [344]