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The design of lymphatic delivery systems ranges from simple systems that rely on passive lymphatic access to more complex structures that integrate into endogenous lymph transport processes

The LECs are positioned in the subcapsular sinus, the interfollicular ridges and the medullary sinus (114, 123, 125, 130), expressing both PDPN and CD31

Summary: Vitamin B12 treatment typically begins producing early haematological responses within 34 days, with neurological symptoms starting to improve within 12 weeks, though complete symptom resolution may require several weeks to months depending on deficiency severity and treatment route

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