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Vitamin C, also called ascorbic acid, is believed to create an acidic environment, triggering the production of nitric oxide, and thereby causing the bacteria present to end their own existence

Intracellularly, CHAC1 enzymatically degrades GSH into 5-oxoproline and Cys-Gly, acting as a pro-ferroptotic execution signal by accelerating GSH exhaustion 151

Its various mechanisms, including its antioxidant effects, the stimulation of pheomelanin synthesis instead of eumelanin, and interference with intracellular trafficking of melanogenic enzymes, contribute to its antimelanogenic properties.3 Hence, through the histopathological examination of melanocyte activity, location of melanin pigment deposition, and response after therapy, we can determine the effects of glutathione on skin color.6,9 However, Arjinpathana and Asawanonda1 reported many contradictory results regarding the efficacy and safety of glutathione as a skin-lightening agent