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However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)

134,135 IL-1 inhibition IL-1 is a cytokine that has the capability of immune and pro-inflammatory actions

Collectively, these approaches offer novel mechanistic insights and therapeutic avenues for targeting ferroptosis propagation in the AD brain

[59] Gla proteins are known to occur in a wide variety of vertebrates: mammals, birds, reptiles, and fish