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Some of the factors that could cause actual results to differ materially from the forward-looking statements contained herein include, without limitation: (i) the contraction or lack of growth of markets in which we compete and in which our products are sold (ii) unexpected increases in our expenses, including manufacturing expenses, (iii) delays or cancellations in spending by our suppliers or customers, (iv) delayed or no approval of our Premarket Tobacco Product Applications, and other filings and submissions, by the U.S

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To investigate the extent to which unspecified opioid deaths could affect our results, we included all unspecified deaths (that is, those with ICD-10 code T50.9 but no other specified drugs) as opioid deaths for ages 3064 and 6579 years (Supplementary Fig

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