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Hence, we assembled a library of 81 fragments featuring epoxide (EO), vinyl sulfone (VS), acrylamide (AA), and -cyanoacrylamide (CA) warheads, as well as electron-deficient heteroarenes capable of SAr reactions (SN)

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Paclitaxel-resistant human ovarian cancer cells have mutant -tubulins that exhibit impaired paclitaxel-driven polymerization

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