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Just one e-cigarette cartridge can make a big dog really sick and can be lethal in a small dog

Although 12 of 15 studies in which the effects of smoking cessation on vascular endothelial function was assessed by physiological methods including measurements of FMD and reactive hyperemia index (RHI) showed that smoking cessation improved FMD, RHI or vascular response to vasoactive agents [18, 21, 22, 25,26,27,28,29, 32,33,34,35], three of those 15 studies showed no effects of smoking cessation on FMD or RHI [89,90,91]

This is so well known it's become almost cliche, but that doesn't make it any less true

Smoking has long been linked to life-threatening health conditions like cancer, cardiovascular disease, and respiratory illness