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To answer this question, let's consider a very large, 100,000 N steel ball that is dropped into the ocean

[Prevalence of cholecystolithiasis in South Germany an ultrasound study of 2,498 persons of a rural population]

To calculate the proportion of trials employing digital technologies, supplementary searches were performed on ClinicalTrials.gov to identify all interventional trials related to each rare disease, with these totals serving as denominators

These therapies included nystatin suspension (4 mL of 100,000 units/mL, 3 times/day, topical) for 5 patients, nystatin suspension with clonazepam (0.5 mg/day, topical) for 1 patient, fluconazole suspension (2.5 mL of 10 mg/mL, 2 times/day, topical) for 1 patient, fluconazole suspension with clonazepam (0.5 mg/day, topical) for 1 patient, and both nystatin and itraconazole suspensions (5 mL of 10 mg/mL, 2 times/day, topical) for 1 patient