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Impact of environmental risk factors on mitochondrial dysfunction, neuroinflammation, protein misfolding, and oxidative stress in the etiopathogenesis of Parkinsons disease

Inhibiting ferroptosis pathways has shown promise in reducing neuronal cell death, protecting brain tissue, and improving functional outcomes in stroke models

Oral administration of LSN3353871 to mice expressing human Lp(a) resulted in dose-dependent increases in the circulating levels of LSN3353871 and dose-dependent decreases of up to 78% in the levels of Lp(a), with a median effective dose (ED 50 ) of 14 mg kg 1 twice daily (BID) within five days of dosing