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Dysregulation in these redox environments decreases the activity of mitochondria, TCA cycle and immune cell metabolism (105)

Overall, the application of COMT inhibitors requires balancing the clinical benefit of extended "on" time against the risk of exacerbating dyskinesia

Front Immunol (2022) 13:955069

Various lipid species, including cholesterol, triglycerides, and FAs, have been proposed as potential biomarkers for ALS, aiding in the assessment of disease onset, progression, and prognosis