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Redox Biol 2015

Older adults also have an increased risk of alcohol use disorder due to an increase in social isolation, divorce or bereavement, and increased rates of depression, reduced alcohol metabolism, and increased alcohol toxicity that lead to an increased risk of alcohol-associated liver disease and a worse prognosis with alcohol-associated liver disease among older adults

5.1.1.4 Amyotrophic lateral sclerosis ALS is a fatal disease characterized by progressive paralysis caused by degeneration of spinal motor neurons

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