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407 Another study comparing outcomes in more than 32,000 diabetic subjects who had undergone knee replacement surgery found those who were taking metformin had better outcomes and lower risk of complications, including DVT

Classical antifolate drugs, including methotrexate (targeting DHFR) [153] and fluoropyrimidine agents (targeting TYMS) [154], induce cell death in rapidly proliferating malignancies by specifically inhibiting key enzymes in 1 C metabolism, thereby depleting nucleotide pools and causing replication stress [101]

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[12] Because many drugs and small peptides can be present in breast milk, caution is advised