glutathione syndrome The Role of Metabolism in Chronic Illness Development and Its Potential Use as a Novel Therapeutic Target Plasma concentration of glutathione (GSH)

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Proton nuclear magnetic resonance ( 1 H NMR, 400 MHz, D 2 O) revealed signals at H 2.21 (q, 2H, H-3), 2.59 (td, 2H, H-4), 2.98 (dd, 2H, CH 2 S), 3.86 (t, 1H, H-2), 4.02 (s, 2H, H-10), and 4.60 (t, 1H, H-7)

R This pathway is the primary defense against: Aflatoxin B1 (a carcinogenic mycotoxin produced by Aspergillus) Cadmium Epoxides (reactive Phase I intermediates from polycyclic aromatic hydrocarbons) Lipid peroxidation products (4-hydroxynonenal, malondialdehyde) Mercury (organic and inorganic forms) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) GSTs exist in three locations: cytosolic (the largest class, with alpha, mu, pi, theta, sigma, omega, and zeta subfamilies), mitochondrial (kappa class), and microsomal (MAPEG family)

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