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DPP1s exclusion domain serves as its unique functional component, precisely regulating exopeptidase activity and ensuring specific N-terminal protein substrate processing by restricting substrate entry patterns ( Regarding cellular distribution, while DPP1 expression occurs across various cell types, expression levels peak in myeloid cells, particularly neutrophils, mast cells, and monocytes ( 2.2 Biological functions and pathological significance of NSPs The NSP family encompasses three key proteases: NE, PR3, and CatG, which serve central roles in neutrophil-mediated innate immunity and inflammatory regulation

A.Bader LangeM

Science 359 , eaan2788 (2018)

Moreover, high levels of basal intracellular ROS have been shown to confer cancer cells with vulnerability to ROS-inducing therapeutic agents such as cisplatin (Salatino et al