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doi: 10.1038/s41420-025-02711-6

Currently, some prospective animal studies have begun exploring schemes combining drug administration with advanced biomaterials, yielding positive preliminary results, but their long-term efficacy and safety still require evaluation in larger-scale, in-depth studies

Research protocols must account for potential beneficial roles of some senescent cells in wound healing and immune responses, requiring careful consideration of administration timing and duration in experimental designs

Statements Author contributions Writingoriginal draft preparation, revisions, figures, review, and editing DKS, Writingreview, and editing RMH, BP, AP, VKY, DW, AEJ