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A: It can cause mild water retention in some patients, usually noticed as slight swelling in the fingers or ankles

Because Ipamorelin does not meaningfully spike cortisol or prolactin at documented research doses, the protocol tends to emphasize pulse timing (getting the GH burst to land at a useful moment, such as during early sleep) rather than aggressive dose escalation

Considerations: Proper spray technique (appropriate angle, avoiding the septum) Alternating nostrils per dose Using a saline rinse periodically to support nasal mucosal health Discontinuation and route change if persistent irritation develops Patients with allergic rhinitis, chronic sinusitis, or significant septal deviation may be poor candidates for nasal delivery and should be considered for injection or oral spray instead