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Under pathological conditions, the following three main mechanisms (oxidative stress, ER stress, and mitochondrial dysfunction) can affect drug metabolism of the liver, and drug metabolites further aggravate liver injury

Isoketals: Highly reactive -ketoaldehydes formed from the H 2-isoprostane pathway

Cui Y, Liu M, Huang H, Zhang D, Chen J, Mao L, Zhou N, Deng F, Zhang X, Wei Y (2020) A novel one-step strategy for preparation of Fe 3 O 4 -loaded Ti 3 C 2 MXenes with high efficiency for removal organic dyes

Oxidative stress response When the body generates more reactive oxygen species than its natural antioxidant defenses can handle, oxidative stress results