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By directly quenching these free radicals, glutathione helps prevent them from stealing electrons from healthy cellular structures, thereby helping to halt the chain reaction of oxidative damage that leads to cellular exhaustion and tissue degradation

PTEN PTEN mediates the conversion of PIP3 to PIP2 which regulates cell proliferation, apoptosis, metabolism, motility and angiogenesis (52)

More importantly, by simultaneously activating both a chemotherapeutic prodrug and an immunoadjuvant prodrug, the strategy maximizes therapeutic efficacy while nearly eliminating systemic side effects-achieving safe and efficient in situ vaccination. Porphyrin-based COFs represent excellent nanoplatforms for PDT and PTT

There have been reports of new second cancers (also called second primary malignancies or SPMs) developing in a small number of myeloma patients who received Revlimid therapy in clinical studies