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In macrophages, reorganization of the actin cytoskeleton necessary for chemotaxis and phagocytosis requires MsrB1-dependent reduction of methionine-R-sulfoxide residues within actin (27)

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Fourth, dexrazoxane or ferrostatin-1 inhibits ferroptosis in a doxorubicin-induced cardiac injury model ( 2+ in mitochondria), but not dexrazoxane and DFO, prevents doxorubicin-induced lipid peroxidation and mitochondria-dependent ferroptosis in cardiomyopathy (Tadokoro et al., 2020), indicating that mitochondrial iron may play a major role in mediating ferroptotic heart damage