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Early diagnosis is important, as therapeutic phlebotomy or iron chelation can halt disease progression, relieve symptoms, and prevent complications such as cirrhosis, hepatocellular carcinoma, heart failure, or diabetes, while allowing family members to be screened to avoid advanced disease [214]

Journal of American Chemical Society

Mechanisms linking environmental agents to the development of Autoimmune Diseases Oxidative stress-mediated disturbance of Nrf2, induction of NF-kB, PARP1, and NLRP3 can cause activation of both innate and adaptive immune systems, resulting in pro-inflammatory cytokines and production of autoantibodies, leading to tissue damage in Autoimmune disease

Studies on endometriosis have shown that metformin exerts potent anti-NF-B effects, alleviating disease progression, and it has demonstrated the potential to target pro-inflammatory molecules in endometriotic cells (Takemura et al., 2007), macrophages, and vascular smooth muscle cells in vitro (Isoda et al., 2006), in obese mice (Hyun et al., 2013), and in rat models of endometriosis (Jamali et al., 2021