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Think of DES as a multiplier

Cox HD, et al

It helps maintain mitochondrial membrane potential and prevent the release of pro-apoptotic factors from mitochondria, thereby preserving cell viability (Pang, 2015)

There is direct evidence that acetate interacts with peptide aggregates: a 2022 study in Molecular Pharmaceutics using 1H NMR and molecular dynamics found that acetate counterions were incorporated into the aggregates of some peptides but not others, showing that the acid is an active participant in solution behavior rather than a passive diluent