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Springer, Cham, pp 152

3) and the absence of any renal drug transporters contributing to renal excretion as suggested from the in vitro study, indicates that, more specifically, elimination of pudexacianinium can be explained almost entirely by glomerular filtration

A practical Evidence Tier system (so you can sanity-check any stack) Tier 1 Strong human evidence + regulatory clarity FDA-approved therapies with defined indications (e.g., tesamorelin for HIV-associated lipodystrophy