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The aqueous extracts of the main components, gastrodia and uncaria, in TMGTY can upregulate Bcl-2 expression, reduce caspase-3 activity, and demonstrates antioxidant and anti-apoptotic capabilities in vitro and in vivo , thereby reducing the infarct area in rats with MCAO, maintaining tissue integrity, and exerting neuroprotective effects (Xian et al., 2016)

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doi: 10.1038/nature06664 173 BillinghamLKStoolmanJSVasanKRodriguezAEPoorTASziborMet al