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In NRK-52E cells, it induced ROS accumulation within 4 h and upregulated GRP78 and CHOP, whereas N-acetylcysteine first suppressed ROS and subsequently attenuated ERS and apoptosis (208)

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This widespread and off-label interest in weight loss drugs has also led to an explosion of unapproved products available online and via social media, which do come with safety risks for consumers