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For example, in addition to specific strategies to prevent drug-drug interactions (DDIs) in cancer remediation medications, this paper underscores the need of risk assessment, particularly because of immunogenicity and organ failure

Comment: Two commenters expressed support for the second alternative discussed in the proposed rule, but requested that it be modified by calculating the first component of the payment limit with the volume-weighted average of the positive ASP data from the previous four quarters for which positive data are available for the biosimilar, rather than only the most recent calendar quarter for which data are available

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The GLP-1RA, tirzepatide, also reduced hypoxic burden and high-sensitivity C-reactive protein (hsCRP) in patients with moderate-to-severe OSA and obesity [88]