These include antidepressants such as duloxetine and milnacipran (serotoninnorepinephrine reuptake inhibitors), tricyclic antidepressants such as amitriptyline, central nervous system depressants such as zolpidem, voltage-gated Ca + channel inhibitors including pregabalin and gabapentin, muscle relaxants such as cyclobenzaprine orally disintegrating tablets, and opioid analgesics such as tramadol and oxycodone
The lack of specific experimental data and uncertainty in quantitative experimentation is difficult for this AOP, as many factors can simultaneously cause key events (such as an increase in ROS or kidney failure)
& Kiselev, M
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