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Another small clinical trial, comprising six patients with GBM who underwent multiple cycles of BBB disruption using MRgFUS to enhance the penetration of TMZ chemotherapy, also found that MRgFUS is safe and well-tolerated without any significant long-term complications at 1-year follow-up [119]

3.4 Immune-function activity Various species of mushrooms, particularly Pleurotus ostreatus and their lectin extracts, can enhance the activity of the defensive system in humans, as demonstrated in in vitro and in vivo studies (19)

They can help by supporting a more balanced gut environment, reducing bacterial overgrowth, and improving digestion

This study suggests that TMAO could be utilized as a biomarker to predict poor outcomes in HfrEF patients (103)