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Hormonal fluctuations can alter collagen synthesis and ligament laxity, while muscle imbalances and poor neuromuscular control can compromise joint stability

By stimulating the innate immune system and encouraging the infiltration of inflammatory cells, interleukin-1 (IL-1) is an essential mediator of inflammation, host defense, and acute-phase responses

14th World Conference on Lung Cancer

However, while young senescent cells can protect organisms from cancer, but with the passage of time, the aging cells can evade the immune system and accumulation in the organization, secretion of proinflammatory cytokines, growth factors and protease, which establish a microenvironment that promote cancer (155) ( Figure 6 )