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SST-14 mRNA is depleted in post-mortem AD cortex and hypothalamus, and decreased SST-14 brain abundance is documented with advanced ageing and declining cognition 57,58,59

The androgen-driven accumulation of more metabolically active VAT may contribute to increased risk of type 2 diabetes by promoting insulin resistance through enhanced lipolysis, elevated NEFA flux to the liver, and increased proinflammatory cytokine production