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Description

These pharmacokinetic features, characterized by rapid clearance and short systemic exposure, further challenge their preclinical-to-clinical applicability

Bremelanotide is a synthetic peptide drug and the first of a new class: melanocortin receptor agonists

Analytical guidance values and standardized procedures for these analytes in hair have to be established, and the contribution of several variability factors must still be clarified

Initial pathway-level interrogation of the metabolomics dataset using the MetaboAnalyst 6.0 platform and the MetPa enrichment tool revealed prominent alterations in bioenergetic circuits, including the TCA cycle, glycolysis/gluconeogenesis, pyruvate metabolism, and fatty acid elongation (Fig