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FDA for long-term therapeutic use

that people with insulin-dependent diabetes are resistant to the suppressive effects of insulin on leucine oxidation and appearance, suggesting a more widespread impairment in amino acid metabolism linked to insulin resistance (62)

It is diagnosed according to the Canadian consensus criteria, at least 6 months after onset when the following symptoms are present: fatigue, post-exertional malaise with a recovery period of at least 24 h, sleep dysfunction, pain, at least two neurological/neurocognitive symptoms and at least two symptoms involving the autonomic, neuroendocrine or immune system [19]

Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement