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However, this shift is accompanied by a significant downregulation of gluconeogenic enzyme expression, resulting in hypoglycemia and lactate accumulation, which have been associated with increased severity of AKI and higher patient mortality (Verissimo et al., 2022)

J Am Soc Nephrol 2:14171422 Hirschberg R, Kopple JD, Blantz RC, Tucker BJ (1991) Effects of recombinant human insulin-like growth factor I on glomerular dynamics in the rat

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Interestingly, much of the research has been based on doses far exceeding the recommended daily intake, both in individuals with pathological conditions and in healthy subjects