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10.1046/j.1523-1747.2002.00077.x 82

Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis

found that these hMOs exhibit greater cellular heterogeneity compared to the monolayer culture and a strong upregulation in hypoxia inducible factor 1 (HIF1) in SNCA-3 neurons [85], which has been associated with PD and brain aging [86]