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Compared with the oral calcium salt formulation (bioavailability 12%37%), fosfomycin trometamol achieves serum concentrations 2- to 4-fold greater, establishing it as the preferred oral formulation for treating uncomplicated urinary tract infections (UTIs) (Neuner et al., 2012)

JHEP Rep 2021;3:100300 10.1016/j.jhepr.2021.100300 [DOI] [PMC free article] [PubMed] [Google Scholar] 45

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But these levels naturally decline with age and drop even further in response to chronic stress, inadequate sleep, poor dietary protein intake, heavy alcohol use, and prolonged exposure to environmental pollutants