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Description

Transforming growth factor -1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis

By six months, the participants had lost 12.7% of their body weight on average

Leveraging transcriptomic datasets through a pharmacogenomics analysis and developing an expert curation of genes previously involved in oligodendroglial biology (provided as a resource for the scientific community: OligoScore, we identified and ranked small bioactive molecules (compounds) for their capacity to foster transcriptional programs associated with various aspects of oligodendrogenesis, including OPC proliferation, differentiation, and (re)myelination