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in contrast, subclinical deficiency is common and may present with hypophosphatemia, hypocalcemia, secondary hyperparathyroidism, bone demineralization, and an increased risk of fractures

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After 90 min of basal sampling, the clamp began at t = 0 with a continuous infusion of human insulin (2.5 mU/kg/min for mice fed chow diet & 4 mU/kg/min for mice fed high-fat diet) after a bolus and the infusion of [3- 3 H] glucose was increased to 0.1 Ci/min for the rest of the experiment