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Clinical manifestations including persistent synovitis and auto-antibody production are displayed by most RA patients and are likely to be a consequence of certain genetic abnormalities that increase the risk of developing this disorder (Lerner and Matthias 2015b)

Each step exists for a specific reason, and skipping any one of them introduces contamination risk or dosing error

Everything below is organized around that reframing, and the dosage calculator exists precisely so the arithmetic never has to be guessed