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566 Specifically, lncRNA SNHG12 enhances X-linked inhibitor of apoptosis protein (XIAP) transcription and stability by interacting with the RNA-binding protein Hu antigen R (HuR), promoting tumor growth and cisplatin resistance in NSCLC cells

The rate-limiting enzyme in this pathway is Indoleamine 2,3-dioxygenase 1 (IDO-1), which is upregulated by pro-inflammatory agents such as interferon- (IFN-) and tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), interleukin-12 (IL-12), all cytokines that are released during inflammatory responses (Yang et al., 2024)

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