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An overdose of tacrolimus can lead to serious complications such as nephrotoxicity, neurotoxicity, infections, high blood sugar, and electrolyte imbalances

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doi: 10.1111/j.1749-6632.1998.tb09913.x 21 HarrisI

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Thats why its pushed at the end of treatment

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The accumulation of NADPH autofluorescence over time is an indicator of aconitase activity, where ACO1/2 present in the sample converts the supplied citrate to isocitrate, which is subsequently metabolized by the supplied IDH1 in a reaction that yields NADPH

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