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We observed an increase in biosynthetic pathways involving alanine, aspartate, glutamate, glutathione, glycerophospholipids, and arginine in both Mock and MST6-I cells treated with secretomes from different adipocyte types [white or TWAT(Mock) or TWAT(MST6-I)] compared with the corresponding untreated cells [Supplementary Figure 2D]

Further research may focus on the direct loading of bioactive peptides or proteins into extracellular vesicles for tissue repair

135 Therefore, the unique metabolic vulnerabilities of cancer cells, which differ from those of normal cells, can be strategically targeted to develop novel and effective therapeutic interventions

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