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In a 23-week randomized clinical trial in humans, individuals taking AOD-9604 at 1 mg daily had an average of 2.8 kg weight reduction compared to a 0.8 kg weight reduction in those taking a placebo

The field of the invention relates generally to quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), the preparation thereof, and the uses thereof

Although we expected the largest microbiome differences to occur in the lean control group relative to the obese control group, we found that the diet-switched groups exhibited a greater number of differences from the control groups than the control groups did from one another

For laboratory and analytical consistency, AOD9604 5 mg is typically supplied as a high-purity peptide , manufactured under controlled conditions