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Selected adults may increase to 7.2 mg after at least four weeks at 2.4 mg when additional weight reduction is clinically indicated. The 0.25 mg dose is the starter rather than the maintenance target

It works especially well for those with a body mass index (BMI) of 30 or more, or for people with a BMI of 27 or higher who also have other linked medical issues, including high blood pressure, high cholesterol , or type 2 diabetes

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Subacute combined degeneration of the spinal cord , a serious complication of untreated B12 deficiency described in NHS and British Society for Haematology guidance, affects both the dorsal columns and corticospinal tracts