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Bortezomib exerts its therapeutic effects in MM by binding to the 5 subunit of the 26S proteasome to inhibit the ubiquitinproteasome pathway, blocking activation of the Nuclear factor kappa-light-chain-enhancer (NF-B) of activated B cells signaling pathway, inducing mitochondrial apoptosis, and suppressing angiogenesis and bone destruction within the tumor microenvironment

Female: n = 6, n = 5) in Aldh2 Tek2 / , *P = 0.0377, *P = 0.0357), smooth muscle (n = 8, n = 9), and skeletal muscle (n = 8, n = 10) (*P = 0.0321, *P = 0.0345) specific Aldh2 KO mice

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Akhtar A, Ghali L, Wang SX, Bell C, Li D, Wen X (2019) Optimisation of folate-mediated liposomal encapsulated arsenic trioxide for treating HPV-positive cervical cancer cells in vitro