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As with any medication, there is also a risk of rare but more serious side effects, such as priapism (prolonged erection), sudden hearing or vision loss, and allergic reactions

However, in some metabolic disorders, Parp2 -knockout mice showed enhanced SIRT1 activity and improved metabolic functions, and were protected against high-fat diet-induced obesity, which were not due to augmented NAD + levels, but to an increase in SIRT1 expression, as PARP2 acts as a direct negative regulator of the SIRT1 promoter [59]

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In fasting animals, the opposite was true, with necrosis being the more prominent response to excessive APAP