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Sulfone-containing 1,3-benzothiazinone derivative as dual cyclooxygenases-2 (COX-2)/tumor necrosis factor-alpha (TNF-) inhibitors To further investigate combined tetrazole-based sulfonamide analogs, a range of tetrazole-bearing compounds were synthesized and evaluated for their in vitro COX inhibitory action, as well as their anti-inflammatory activity by measuring IL-6 and TNF- expression levels (101)